An Efficient One-Pot Three-Component Reaction for Synthesis of Spirooxindole Derivatives in Water Media under Catalyst-Free Condition

作者：Zhao, Liqin; Zhou, Bo; Li, Yiqun^*

来源：Heteroatom Chemistry, 2011, 22(5): 673-677.

DOI：10.1002/hc.20723

• Catalysis in water
• Catalyst-free
• Environmentally benign synthesis
• Low costs
• Malononitriles
• One pot
• Short reaction time
• Three component reactions
• Water media

An efficient, clean, and environmentally benign synthesis of spirooxindole derivatives by one-pot three-component reaction of isatins, malononitrile, and carbonyl compound in the absence of catalysis in water was described. A variety of spirooxindole derivatives were obtained with excellent yields within short reaction time. This novel protocol has the advantages of convenient operation, low cost, and environmental benign.

• 出版日期2011
• 单位暨南大学