Deficit of interleukin 7 in septic patients

作者：Andreu Ballester Juan C^*; Cuellar Carmen; Garcia Ballesteros Carlos; Perez Griera Jaime; Amigo Victoria; Peiro Gomez Ana; Penarroja Otero Carlos; Ballester Ferran; Mayans Jose; Tormo Calandin Constantino

来源：International Immunopharmacology, 2014, 23(1): 73-76.

DOI：10.1016/j.intimp.2014.08.015

• Interleukin 7
• Sepsis
• Gamma-delta T cells

We recently demonstrated an overall decrease of all alpha beta and specially gamma delta T cell subsets in patients with sepsis compared with healthy subjects. IL-7 is a crucial factor for development of gamma delta T cells and survival in sepsis but its association with sepsis severity, evolution of organ failure and death still has not been investigated. Sera from 78 patients who met criteria for sepsis were analyzed vs control group. Septic patients showed the lowest levels of IL-7. Patients with severe sepsis reached levels of IL-7 higher than those observed in the groups of uncomplicated sepsis and septic shock. The frequency gamma delta T cells at admission was lower in septic patients vs control group. At the time of admission, the frequency of gamma delta T cells in septic patients who subsequently died was lower than the observed in the group of patients that instead survived.

• 出版日期2014-11