Facile synthesis of trifluoroethyl aryl ethers through copper-catalyzed coupling of CF3CH2OH with aryl- and heteroaryl boronic acids

作者：Wang, Ruixin; Wang, Liang; Zhang, Kena; Li, Jingya; Zou, Dapeng^*; Wu, Yangjie; Wu, Yusheng

来源：Tetrahedron Letters, 2015, 56(33): 4815-4818.

DOI：10.1016/j.tetlet.2015.06.066

• Trifluoroethyl aryl ether derivatives
• Chan-Lam coupling reaction
• Arylboronic acids

An efficient copper-catalyzed Chan-Lam reaction of trifluoroethanol with a variety of aryl- and heteroaryl boronic acids has been developed. This research provides a practical method to synthesize trifluoroethyl aryl ethers in moderate to good yields under mild conditions.

• 出版日期2015-8-12
• 单位郑州大学