An efficient synthesis of (E)-(2-arylpyrazino[1,2-a]pyrimidine-4-ylidene)acetonitriles and cyanomethyl appended pyrimidines

作者：Pratap Ramendra; Kushwaha Shom Prakash; Goel Atul; Ram Vishnu Ji^*

来源：Tetrahedron Letters, 2007, 48(4): 549-553.

DOI：10.1016/j.tetlet.2006.11.136

• 4-pyrimidinyl acetonitrile
• pyrazino[1,2-alpha]pyrimidines
• 2H-pyran-2-ones
• ring transformation

A series of (E)-(2-arylpyrazino[1,2-a]pyrimidine-4-ylidene)acetonitriles 5a-j and aryl/heteroaryl tethered pyrimidin-4-yl acetonitriles 6a-e has been synthesized in excellent yields through base catalyzed ring transformation of suitably functionalized 2H-pyran-2-ones 3 using 2-aminopyrazine 4a and arylamidinium salts 4b, separately.

• 出版日期2007-1-22