Phospholipase A(2) activity in first episode schizophrenia: Associations with symptom severity and outcome at week 12

作者：Smesny Stefan^*; Kunstmann Christina; Kunstmann Sebastian; Willhardt Ingo; Lasch Juergen; Yotter Rachel A; Proffitt Tina Marie; Kerr Melissa; Marculev Conny; Milleit Berko; Milleit Christine; Nenadic Igor; Amminger Paul; Mcgorry Patrick D; Sauer Heinrich; Berger Gregor E

来源：World Journal of Biological Psychiatry, 2011, 12(8): 598-607.

DOI：10.3109/15622975.2010.541283

• Schizophrenia
• phospholipase A(2)
• longitudinal
• negative symptoms
• functional impairment

Objectives. Intracellular phospholipases A(2) (inPLA(2)) are activated during monoaminergic neurotranismision and act as key enzymes in cell membrane repair and remodelling, neuroplasticity, neurodevelopment, apoptosis, synaptic pruning, neurodegenerative processes and neuroinflammation. Several independent studies found increased inPLA(2) activity in drug-naive first episode and chronic schizophrenia. This study investigates if inPLA(2) activity is associated with symptoms severity and treatment response in first episode schizophrenia (FES). Methods. InPLA(2) activity was measured in serum of 35 young FES patients (mean age: 19.36 +/- 3.32, mean duration of illness: 7.53 +/- 6.28 months, 16 neuroleptic-naive) before and after 12 weeks of treatment with second-generation antipsychotic medications (olanzapine, quetiapine or risperidone), as well as in 22 healthy controls matched for age. Psychopathology and social functioning were assessed at the same time points. Results. Baseline inPLA(2) activity was significantly increased in drug-naive and treated FES patients compared to healthy controls. Baseline inPLA(2) activity was also associated with severity of negative symptoms and lower functioning at baseline. Furthermore, baseline inPLA(2) activity was associated with improvement in negative symptoms and functioning within the first 12 weeks of treatment. Conclusions. Intracellular PLA(2) activity is increased in first episode schizophrenia and associated with symptom severity and outcome after 12 weeks of treatment. Future studies should investigate the implications of inPLA(2) activity as a potential predictor of treatment response for different antipsychotic agents.

• 出版日期2011-12