A bioinformatics study concerning the structural and functional properties of human caveolin proteins

作者：Isvoran Adriana^*; Craciun Dana; Ciorsac Alecu; Perrot Nahuel; Beswick Veronica; Nedellec Pierre; Sanson Alain; Jamin Nadege

来源：Journal of the Serbian Chemical Society, 2014, 79(2): 133-150.

DOI：10.2298/JSC1307161001

• secondary structure
• disordered regions
• functional domains

A bioinformatics study was performed to predict and compare the structural and functional properties of human caveolins: caveolin-1, -2 and -3. The computed local physicochemical properties, predictions of their secondary structure elements and interacting partners of caveolin-2 and -3 were compared to the experimentally determined structural and functional properties of caveolin-1. These data combined with sequence alignments of the three caveolins allowed the functional domains of caveolin-2 and -3 to be predicted and characterised. The hydrophobic regions of these proteins are highly similar in sequences and physicochemical properties, which is in good agreement with their known membrane locations and functions. The most divergent in terms of sequences and properties are the C-terminal regions of the caveolins, suggesting that they might be responsible for their distinct predicted interactions, with direct consequences on signalling processes.

• 出版日期2014
• 单位中国地震局