A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss

作者：Ueberfuhr Margarete A; Fehlberg Hannah; Goodman Shawn S; Withnell Robert H^*

来源：Hearing Research, 2016, 332: 137-150.

DOI：10.1016/j.heares.2015.11.006

• Otoacoustic emission
• Presbycusis
• Model

Distortion product otoacoustic emissions (DPOAEs) were used to assess outer hair cell (OHC) integrity in human ears with age-related hearing loss. Sound pressure measurements were made in the ear canal over the stimulus range 40-90 dB SPL (L-2), with L-1 = 0A5*L-2 + 44 with F-2 = 2 and 3 or 4 kHz. Model generated DPOAE I/O functions were fit to DPOAE data to quantify the contribution of loss of nonlinearity (OHC loss) to the hearing loss. Results suggest OHC loss as a contributing cause of age-related hearing, regardless of audiogram configuration. It seems likely that OHC and stria] pathology co-exist in ears with AHL.

• 出版日期2016-2