Toll-like receptor 4 polymorphisms and susceptibility to multiple autoimmune diseases: evidence based on pooled analysis

作者：Wang Xiao Qin; Zhang Kui^*; Xiong Ding

来源：Central European Journal of Immunology, 2013, 38(3): 380-387.

DOI：10.5114/ceji.2013.37757

• autoimmune diseases
• Toll-like receptor 4
• single nucleotide polymorphism
• meta-analysis
• SNP

Background: Toll-like receptor 4 (TLR4) is known to activate the nuclear factor kappa B (NF-kappa B) and subsequent gene expression such as cytokines and adhesion molecules. That may subsequently reduce the risk of autoimmune diseases (ADs). However; the results of molecular epidemiological studies remain inconsistent.
Material and methods: The PubMed, Embase, CNKI databases were searched for all articles available. The OR corresponding to the 95% confidence interval (95% CI) was used to assess the association between TLR4 polymorphisms and the risk of ADs.
Results: The TLR4 Asp299Gly and TLR4 Thr399Ile polymorphisms were not associated significantly with a risk of ADs (Asp299Gly: OR = 0.86, 95% CI: 0.74-1.00 for G vs. A and OR = 0.87, 95% CI: 0.74-1.01 for AG/GG vs. AA, respectively; Thr399Ile: OR = 0.77, 95% CI: 0.57-1.05 for T vs. C and OR = 0.79, 95% CI: 0.58-1.09 for TT/CT vs. CC, respectively).
Conclusions: This meta-analysis suggested that TLR4 Asp299Gly and TLR4 Thr399Ile polymorphisms were not involved in the development of ADs. However; well-designed studies with a larger sample size should be conducted to confirm this result.

• 出版日期2013
• 单位遵义医科大学