Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea

作者：van den Biggelaar Anita H J^*; Richmond Peter C; Pomat William S; Phuanukoonnon Suparat; Nadal Sims Marie A; Devitt Catherine J; Siba Peter M; Lehmann Deborah; Holt Patrick G

来源：Vaccine, 2009, 27(9): 1340-1347.

DOI：10.1016/j.vaccine.2008.12.046

• Pneumococcal conjugate vaccine
• Neonatal
• T cells

The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM(197) compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses.

• 出版日期2009-2-25
• 单位河北医科大学