A mild and efficient one-pot synthesis of beta-amino carbonyl compounds via Mannich reaction under ambient temperature condition

作者：Goswami Santosh V; Thorat Prashant B; Chakrawar Avinash V; Bhusare Sudhakar R^*

来源：Molecular Diversity, 2013, 17(1): 33-40.

DOI：10.1007/s11030-012-9414-x

• Mannich reaction
• Aromatic aldehydes
• Aromatic amines
• beta-Amino carbonyl compounds
• Phenylboronic acid
• Multicomponent reaction

We have developed an efficient protocol for the synthesis of -amino carbonyl compounds using phenylboronic acid as effective and eco-friendly catalyst via one-pot three-component Mannich reaction. Excellent yields, mild reaction condition, and simple experimental work-up procedure are some of the advantages of this method, which makes it a useful protocol for the synthesis of -amino carbonyl compounds.

• 出版日期2013-2