A Practical Chemo-enzymatic Synthesis of Homochiral Bicyclo[2.2.2]octane-2,5-dione

作者:Luo Yunfei; Carnell Andrew J*
来源:Journal of Organic Chemistry, 2010, 75(6): 2057-2060.
DOI:10.1021/jo9023705

摘要

A practical synthetic route for the preparation of chiral bicyclo[2.2.2]octane-2,5-dione, the precursor of useful chiral diene ligands, was realized via Diels-Alder reaction and resolution of an enol acetate derivative by immobilized lipases.

  • 出版日期2010-3-19