Anti-Candida zeylanoides activity of some Iranian plants used in traditional medicine

作者：Shokri H^*; Sharifzadeh A; Tamai I Ashrafi

来源：Journal de Mycologie Medicale, 2012, 22(3): 211-216.

DOI：10.1016/j.mycmed.2012.04.006

• Antifungal activity
• Candida zeylanoides
• Medicinal plants
• Essential oils

Objective. - To assess anti-Candida zeylanoides activity of the essential oils (EOs) of five Iranian medicinal plants and to determine the different components of the EOs. %26lt;br%26gt;Methods. - Anti-C. zeylanoides effects of the EOs and reference drugs were determined by disc diffusion method. The EOs from Trachyspermum copticum, Zataria multiflora, Nigella sativa, Ziziphora clinopodiodes and Heracleum persicum were analyzed by gas chromatography/mass spectroscopy (GC/MS). %26lt;br%26gt;Results. - The mean values of inhibition zones were found to be more than 60 mm for T. copticum, 56.7 mm for Z. multiflora, 40.8 mm for N. sativa, 33.7 mm for Z. clinopodiodes and 18.7 mm for H. persicum. In GC/MS analysis, thymol (63.4%), carvacrol (61%), trans anthol (39%), pulegone (37%) and hexyl butyrate (30.2%) were found to be the major components of T. copticum, Z. multiflora, N. sativa, Z. clinopodiodes and H. persicum, respectively. %26lt;br%26gt;Conclusion. - The EOs showed strong anti-C. zeylanoides activities, which strengthen the potential use of these substances for the treatment of candidiasis.

• 出版日期2012-9