MicroRNAs Regulate Immune System Via Multiple Targets

作者：Jia, Sujie; Zhai, Hanyue; Zhao, Ming^*

来源：Discovery Medicine, 2014, 18(100): 237-247.

• PATTERN-RECOGNITION RECEPTORS
• ANTIVIRAL INNATE IMMUNITY
• DENDRITIC CELLS
• PROTEIN EXPRESSION
• GAMMA PRODUCTION
• GENE-EXPRESSION
• T-CELLS
• ACTIVATION
• MIR-155
• DIFFERENTIATION

MicroRNAs (miRNAs) represent the most abundant class of regulators of gene expression. Each miRNA may suppress multiple mRNA targets, while one mRNA can be targeted by many miRNAs for precise control of a wide range of cellular processes. The important role of miRNAs in the immune system is highlighted by the conditional Dicer knockout mouse, which exhibited profound aberrant development and function of immune cells. One particular miRNA, miR-155, is highly expressed and plays important role in lymphocytes. In this review we focused on the role of miRNA, especially miR-155, via their predicted and known mRNA targets in innate and adaptive immunity. Finally, we discussed the potential of miRNAs as novel targets for the diagnosis and therapy of immune system diseases.

• 出版日期2014-11
• 单位中南大学