科研之友
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摘要
A convenient synthesis of 1-aryl-1H-1,2,3-triazoles through the one pot cascade reactions of alkynes with aliphatic azides and allenic ketones is presented. Mechanically, the formation of the title compounds involves a copper-catalyzed cycloaddition of alkyne with 4-azido-3-oxobutanoate to give 3-oxo-4-( 1H-1,2,3-triazol-1-yl) butanoate as a key intermediate followed by its [3 + 3] annulation with allenic ketone through Michael addition and intramolecular condensation. A comparison study showed that using aliphatic azide as the substrate is superior to aromatic azide in terms of efficiency and selectivity. Furthermore, the 1-aryl-1H-1,2,3-triazoles bearing a 2'-bromophenyl unit attached on the 2-position of the in situ formed aryl ring obtained herein could be readily transformed into the biologically and pharmaceutically valuable tretracyclic triazolophenanthridines with good yields via a Pd-catalyzed C-H arylation.
