A retrospective study on 73 elderly patients (>= 75 years) with aggressive B-cell non Hodgkin lymphoma: Clinical significance of treatment intensity and comprehensive geriatric assessment

作者：Marchesi Francesco^*; Cenfra Natalia; Altomare Lidia; Dessanti Maria L; Mecarocci Sergio; Cerchiara Elisabetta; Rago Angela; D'Andrea Mariella; Tomarchio Valeria; Olimpieri Odoardo M; Tirindelli Maria C; Mengarelli Andrea; Petti Maria C; Avvisati Guiseppe; Cimino Guiseppe

来源：Journal of Geriatric Oncology, 2013, 4(3): 242-248.

DOI：10.1016/j.jgo.2013.04.003

• Aggressive B-cell non-Hodgkin
• lymphoma
• Anthracyclines-based chemotherapy
• Conservative regimens without
• anthracyclines
• Comprehensive geriatric assessment
• Very elderly patients

Objective: The clinical outcome of elderly (>= 75 years) patients with aggressive B-cell non-Hodgkin lymphoma (B-NHL) is not firmly established because few studies have specifically addressed this issue. In addition, the usefulness of a comprehensive geriatric assessment (CGA) in B-NHL still needs to be deeply explored.
Materials and Methods: We evaluated the prognostic factors of 73 patients aged >= 75 years (median age: 78) with B-NHL treated by clinical judgment with curative anthracycline-based approaches (n = 36) or with conservative treatments without anthracyclines (n = 37). Analysis of clinical outcomes also included baseline CGA stratification.
Results: The curative approaches resulted in a better clinical outcome than conservative approaches [Overall response rate: 91.2% vs. 69.7%, P = 0.003; 2-year progression-free survival: 47.2% vs. 21.6%, P = 0.006; and 2-year overall survival (OS): 58.3%s 24.3%, P = 0.003] with similar safety profiles. Independent of treatment type, patients classified as "fit" and "intermediate" by CGA presented with better OS compared to patients classified as "frail" (P < 0.001). Patients classified as "fit" and "intermediate" who were receiving curative. treatments presented with a significantly better OS when compared with those treated conservatively on the basis of clinical judgment. A curative anthracycline-based therapy (P = 0.048), the response to treatment (P = 0.017) and a "frail" condition (P = 0.031) were the only factors affecting OS in multivariate analysis.
Conclusions: Present data indicates that even in elderly patients with B-NHL curative anthracycline-based therapies are more effective than conservative approaches. However, choice of treatment should rely more on objective than on subjective parameters. Therefore, further prospective trials are Warranted to better define the CGA role in hematopoietic malignancies.

• 出版日期2013-7