Angiogenesis function of salidroside in myocardium of rats with myocardial ischemia

作者：Yang, Lei; Mao, Bingyu^*; Liu, Nuan

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(3): 4957-4962.

• Salidroside
• myocardial infarction
• angiogenesis
• vascular endothelial growth factors
• CD34

This study is to determine the effect of salidroside (SAL) on myocardium of rats with myocardial infarction (MI) and to analyze its possible mechanism. Left coronary artery of Sprague-Dawley rats was ligated to establish MI model. The rats were randomly divided into model group, SAL groups (10, 20, and 40 mg/(kg/d) groups), and the sham-operated group, with 8 rats per group. Hemodynamic changes in rats were determined, and the segmental heart samples were used for H&E or Masson staining. Expression of vascular endothelial growth factors (VEGF) and cluster of differentiation 34 (CD34) were analyzed by semi-quantitative PCR and Western blot. Compared with the sham-operated group, myocardial tissue was damaged and the collagen volume fraction was significantly increased (P<0.01). Compared with the model group, the number of angiogenesis in all the SAL treatment groups was significantly increased while the collagen volume fraction was significantly decreased (P<0.01). In addition, mRNA and protein levels of VEGF and CD34 in the cytoplasm of SAL treated myocardial tissues were significantly increased compared with the model group (P<0.01). SAL can obviously promote angiogenesis in myocardial tissue of rats after MI.

• 出版日期2017
• 单位南阳理工学院