Mitochondrial factors in the regulation of innate immunity

作者：Scott Iain^*

来源：Microbes and Infection, 2009, 11(8-9): 729-736.

DOI：10.1016/j.micinf.2009.04.022

• MAVS
• IPS-1
• Cardif
• VISA
• Mitochondria
• Innate Immunity
• CARD domain

Viral infection stimulates multiple signalling pathways in the innate immune system, leading to type I interferon production. Recent research has identified the mitochondrial protein MAVS as a key component of one intracellular pathway, definitively linking mitochondria to the mammalian antiviral defence system for the first time. Published by Elsevier Masson SAS.

• 出版日期2009-8