科研之友
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摘要
The properties of hammerhead ribozymes are described. Various hammerhead ribozyme constructs for target RNA cleavage were considered. Approaches to enhancement of the stability of artificial ribozymes in biological media and to regulation of the catalytic activity of hammerhead ribozymes using effect or molecules are described. The effect of ribozymes on extended structured natural RNAs is discussed. Applications of artificial hammerhead ribozymes as inhibitors of gene expression at matrix RNA level were considered. The bibliography includes 217 references.
- 出版日期2011
