Notch-ing from T-cell to B-cell lymphoid malignancies

作者：Mirandola Leonardo; Comi Paola; Cobos Everardo; Kast W Martin; Chiriva Internati Maurizio; Chiaramonte Raffaella^*

来源：Cancer Letters, 2011, 308(1): 1-13.

DOI：10.1016/j.canlet.2011.05.009

• Notch
• Lymphoid malignancies
• Multiple myeloma
• Gamma-secretase
• Drug resistance

Notch receptors are transmembrane proteins critically determining cell fate and maintenance of progenitor cells in many developmental systems. Notch signaling is involved in stem cell self-renewal and regulates the main functions of cell life at different levels of development: cell proliferation, differentiation and apoptosis. By virtue of its involvement in the regulation of cell physiology, it is not surprising that a deregulation of the Notch pathway leads to the development of different tumors. In this review, we critically discuss the latest findings concerning Notch roles in hematologic oncology, with a special focus on T-cell acute lymphoblastic leukemia and B-cell malignancies. We also describe the molecular mediators of Notch-driven oncogenic effects and the current pharmacological approaches targeting Notch signaling.

• 出版日期2011-9-1