A simple one-pot preparation of N-allenyl amides, ureas, carbamates and sulfonamides using a DMSO/(BuOK)-Bu-t protocol

作者：Bousfield Thomas W; Kimber Marc C^*

来源：Tetrahedron Letters, 2015, 56(2): 350-352.

DOI：10.1016/j.tetlet.2014.11.093

• Amide
• Allenamide
• Propargyl bromide
• One-pot
• Lactam

A one-pot transformation of amides, ureas, carbamates and sulfonamides into synthetically useful N-allenyl analogues using a (BuOK)-Bu-t/DMSO protocol is reported. The procedure is experimentally simple and robust, and provides N-allenyl analogues, commonly used within the literature, in yields comparable to the benchmark two-step approach.

• 出版日期2015-1-8