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摘要
Background: Some studies have suggested that human HLA status might potentiate development of keloids phenotype, and exists ethnic differences. No report has been published about HLA-DQA1 and DQB1 alleles associated with keloids in Chinese Hans.
Objectives: To investigate whether HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to keloids in Chinese Hans.
Methods: Polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used to analyze the distribution of HLA-DQA1 and DQB1 alleles among 192 patients with keloids and 273 healthy controls in Chinese Hans.
Results: (1) The frequencies of HLA-DQA1*0104, DQB1*0501 and DQB1*0503 (OR = 2.13, P-c = 0.0063; OR = 14.42, P-c < 10(-7) and OR = 6.09, P-c < 10(-7), respectively) were significantly higher, while the frequencies of DQA1*0501, DQB1*0201 and DQB1*0402 (OR=0.46, P-c=0.0099; OR=0.24, P-c < 10(-4) and OR=0.10, P-c = 0.0054, respectively) were lower in patients than in controls. (2) In this study significant susceptibility haplotypes to keloids were DQA1*0104-DQB1*0501 and DQA1*0104-DQB1*0503. (3) HLA-DQB1*0501 and DQB1*0503 were positively associated with all subgroups of keloid patients. However, the DQA1*0104 (OR = 2.51, P-c = 0.0009; OR = 2.22, P-c = 0.0090 and OR = 2.20, P-c = 0.0117, respectively) was only prevalent in keloid patients with single site, moderate severity and negative family history. (4) HLA-DQB1*0201 (OR=0.27, P-c=0.0018 and OR=0.27, P-c=0.0012, respectively) and DQB1*0402 (OR=0.07, P-c=0.0270 and OR=0.07, P-c=0.0306, respectively) were negatively associated with moderate severity and negative family history in keloids, moreover, HLA-DQB1*0201 (OR = 0.23, P-c = 0.0003) and DQA1*0501 (OR = 0.43, P-c = 0.0234) were less prevalent in patients with single site.
Conclusion: This study demonstrated the positive association of HLA-DQA1 and DQB1 alleles and haplotypes with keloids.
- 出版日期2008-11
- 单位安徽医科大学
