A facile, efficacious and reusable Sm2O3/ZrO2 catalyst for the novel synthesis of functionalized 1,4-dihydropyridine derivatives

作者：Shabalala Sebenzile; Maddila Suresh; van Zyl Werner E; Jonnalagadda Sreekantha B

来源：Catalysis Communications, 2016, 79: 21-25.

DOI：10.1016/j.catcom.2016.02.017

• Green synthesis
• Functionalized pyridines
• Multicomponent reactions
• Heterogeneous catalyst
• Recyclability
• Sm2O3/ZrO2
• Mixed oxide catalyst

An efficient four component/one-pot protocol was developed for synthesis of novel functionalized 1,4-dihydropyridines at room temperature by a reaction of malononitrile, substituted aldehydes, dimethylacetylenedicarboxylate and 4-fluoroaniline in ethanol and using Sm2O3/ZrO2 as catalyst. All reactions were completed in <20 min. The structures of all the new compounds were confirmed by different spectral analyses. The catalyst, Sm2O3/ZrO2 was synthesized and characterized by various techniques including powder X-ray diffraction, N-2 adsorption/desorption, scanning electron microscopy, and transmission electron microscopy analysis. The key advantages of this process are good to high yields (87 to 96%), short reaction times, easy work-up, reusability and no chromatographic purification.

• 出版日期2016-4-5