Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction

作者：Pei, Yuxin^*; Fan, Fengfeng; Wang, Xinxin; Feng, Weiwei; Hou, Yong; Pei, Zhichao^*

来源：Polymers, 2017, 9(10): 469.

DOI：10.3390/polym9100469

• molecular imprinting
• hypericin
• click reaction
• nanospheres

To fabricate molecularly imprinted polymer nanospheres via click reaction, five different clickable compounds were synthesized and two types of click reactions (azide-alkyne and thiol-yne) were explored. It was found that molecularly imprinted polymer nanospheres could be successfully synthesized via thiol-yne click reaction using 3,5-diethynyl-pyridine (1) as the monomer, tris(3-mercaptopropionate) (tri-thiol, 5) as the crosslinker, and hypericin as the template (MIP-NSHs). The click polymerization completed in merely 4 h to produce the desired MIP-NSHs, which were characterized by FTIR, SEM, DLS, and BET, respectively. The reaction conditions for adsorption capacity and selectivity towards hypericin were optimized, and the MIP-NSHs synthesized under the optimized conditions showed a high adsorption capacity (Q = 6.03 mol<bold>g</bold>-1) towards hypericin. The imprinting factors of MIP-NSHs towards hypericin, protohypericin, and emodin were 2.44, 2.88, and 2.10, respectively.

• 出版日期2017-10
• 单位西北农林科技大学