Hepatitis C-induced liver cirrhosis combined with hereditary spherocytosis: a case report

作者：Yang, Dong; Gu, Yanan; Wang, Zhen^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(6): 9675-9680.

• Hepatitis C
• liver cirrhosis
• hereditary spherocytosis

Hereditary spherocytosis is a rare genetic disorder. There are no reported cases of hepatitis C virus (HCV)induced liver cirrhosis combined with hereditary spherocytosis. A 64-year-old woman was hospitalized with symptoms of liver cirrhosis and biliary tract infection. Subsequent examination revealed severe anemia to a degree that was incongruent with HCV-induced liver cirrhosis. Bone marrow aspiration indicated a hemolytic anemia, with 14% spherocytes in the peripheral blood. The patient underwent splenectomy. The surgeons observed hepatic nodular sclerosis and obvious splenic congestion and enlargement. Because of the pre-existing HCV-induced liver cirrhosis, splenectomy partly alleviated the anemia. Hereditary spherocytosis may be masked by symptoms of biliary tract infection and pre-existing HCV-induced liver cirrhosis, particularly if overlooked until symptoms become severe. Although patients with liver cirrhosis may present with a reduction in the number of granulocytes, erythrocytes, and platelets as a result of hypersplenism, when the pattern does not match the patient's condition, physicians should consider the possibility of combined hematologic diseases.

• 出版日期2017
• 单位大连医科大学