A facile access to pyrroles from amino acids via an aza-Wacker cyclization

作者：Zhang Zuhui; Zhang Jintang; Tan Jiajing; Wang Zhiyong^*

来源：Journal of Organic Chemistry, 2008, 73(13): 5180-5182.

DOI：10.1021/jo800433b

A facile and efficient synthesis of pyrroles from readily available amino acids is described. The key step in the method is an aza-Wacker oxidative cyclization catalyzed by palladium(II)/Cu(OTf)(2). A series of pyrroles were obtained by this method under mild conditions.

• 出版日期2008-7-4
• 单位中国科学技术大学