Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications

作者：Papathomas Thomas G; Venizelos Ioannis; Dunphy Cherie H; Said Jonathan W; Wang Michael L; Campo Elias; Swerdlow Steven H; Chan John C; Bueso Ramos Carlos E; Weisenburger Dennis D; Medeiros L Jeffrey; Young Ken H^*

来源：Human Pathology, 2012, 43(4): 467-480.

DOI：10.1016/j.humpath.2011.08.024

• Mantle cell lymphoma
• Composite lymphoma
• Clonal relationship
• Small lymphocytic lymphoma
• Chronic lymphocytic leukemia
• Follicular lymphoma
• Plasma cell neoplasm
• Marginal zone lymphoma
• Classical Hodgkin lymphoma
• Plasmablastic lymphoma
• Burkitt lymphoma

Composite lymphoma is a rare circumstance in which 2 or more distinct types of lymphoma occur in a single anatomical location. Although composite lymphoma has been increasingly identified with the advent of molecular genetic techniques, this topic has only rarely been a specific focus of the medical scientific literature. In this review, we focus on mantle cell lymphoma occurring as a major pathologic component of composite lymphoma and emphasize the clinicopathologic features of these tumors and associated biologic implications. To date, 26 cases of composite lymphoma including a component of mantle cell lymphoma have been previously published. Issues of clonal relatedness between the individual lymphoma components and emerging biologic implications as well as potential diagnostic pitfalls are evaluated.

• 出版日期2012-4