A Photostable Far-Red/Near-Infrared Conjugated Polymer Photosensitizer with Aggregation-Induced Emission for Image-Guided Cancer Cell Ablation

作者：Wu, Wenbo; Feng, Guangxue; Xu, Shidang; Liu, Bin^*

来源：Macromolecules, 2016, 49(14): 5017-5025.

DOI：10.1021/acs.macromol.6b00958

• ACTIVATED DELAYED FLUORESCENCE
• LIGHT-EMITTING-DIODES
• MOLECULAR DESIGN
• NANOPARTICLES
• DOTS
• POLYELECTROLYTES
• BRIGHT
• RED
• THERAPY
• AIE

Far-red (FR)/near-infrared (NIR) photosensitizer is highly desirable in image-guided photodynamic cancer therapy. Herein, a new conjugated polymer of poly(1,2-bis(4-((6-bromohexyl)oxy)phenyl)-1,2-diphenylethene-co-a/t-9,10-anthraquinone) (PTPEAQ) consisting of tetraphenylethylene (TPE), an iconic aggregation-induced emission (AIE) active group as the electron donor, and anthraquinone (AQ) as the acceptor, is prepared for the first time through one-pot Suzuki polymerization. Encapsulation of PTPEAQ with a block copolymer followed by surface functionalization with anti-Her2 affibody yields PTPEAQ-NP-HER2. It shows bright AIE-active FR/NIR emission and efficient singlet oxygen generation under visible light irradiation, which has been successfully used for photodynamic cancer cell ablation using SKBR-3 cells, a type of breast cancer cell with HER2 overexpression on cell membrane, as an example.

• 出版日期2016-7-26