A novel recurrent chromosomal aberration involving chromosome 7 in childhood myelodysplastic syndrome

作者：Lizcova Libuse^*; Zemanova Zuzana; Malinova Eva; Jarosova Marie; Mejstrikova Ester; Smisek Petr; Pospisilova Dagmar; Stary Jan; Michalova Kyra

来源：Cancer Genetics and Cytogenetics, 2010, 201(1): 52-56.

DOI：10.1016/j.cancergencyto.2010.05.004

Monosomy 7 and/or deletion of the long arm of chromosome 7 is a common cytogenetic aberration in children with myelodysplastic syndrome (MDS) and is associated with poor outcome. In this report, we present an unusual cytogenetic abnormality leading to loss of both the whole short and whole long arms of chromosome 7, which was found in the bone marrow cells of three pediatric patients with MDS. Using a combination of conventional and molecular cytogenetic methods, a tiny "dot-like" marker chromosome was found and described as der(7)del(7)(p11)del(7)(q11). Together with one previously published case, this chromosomal aberration represents a new rare recurrent karyotypic abnormality involving chromosome 7 in children with MDS.

• 出版日期2010-8