Association of Single Nucleotide Polymorphisms with Atrial Fibrillation and the Outcome after Catheter Ablation

作者：Hu Yu Feng; Wang Hsueh Hsiao; Yeh Hung I; Lee Kun Tai; Lin Yenn Jiang; Chang Shih Lin; Lo Li Wei; Tuan Ta Chuan; Li Cheng Hung; Chao Tze Fan; Chung Fa Po; Liao Jo Nan; Tang Paul Wei Hua; Tsai Wei Chung; Chiou Chuen Wang; Chen Shih Ann^*

来源：Acta Cardiologica Sinica, 2016, 32(5): 523-531.

DOI：10.6515/ACS20150827A

• Atrial fibrillation
• Catheter ablation
• Single nucleotide polymorphism

Background: The association of gene variants with atrial fibrillation (AF) type and the recurrence of AF after catheter ablation in Taiwan is still unclear. In this study, we aimed to investigate the relationships between gene variants, AF type, and the recurrence of AF.
Methods: In our investigation, we examined 383 consecutive patients with AF (61.9 +/- 14.0 years; 63% men); of these 383 patients, 189 underwent catheter ablation for drug-refractory AF. Thereafter, the single nucleotide polymorphisms rs2200733, and rs7193343 were genotyped using real-time polymerase chain reaction.
Results: The rs7193343 variant was independently associated with non-paroxysmal AF (non-PAF). In the PAF group, the rs7193343 variant was independently associated with AF recurrence after catheter ablation. However, the rs2200733 variant was not associated with AF recurrence in this group. The combination of the rs7193343 and rs2200733 risk alleles was associated with a better predictive power in the PAF patients. In contrast, in the non-PAF group, the SN Ps were not associated with recurrence. The rs7193343 and rs2200733 variants were not associated with different atrial voltage and activation times.
Conclusions: The rs7193343 variants were associated with AF recurrence after catheter ablation in PAF patients but not in non-PAF patients. The rs7193343 CC variant was independently associated with non-PAF.

• 出版日期2016-9