Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population

作者：Sun, Ying; Yuan, Yi; Yang, Hua; Li, Jingjie; Feng, Tian; Ouyang, Yongri; Jin, Tianbo^*; Liu, Ming

来源：Journal of Clinical Research in Pediatric Endocrinology, 2016, 8(4): 405-410.

DOI：10.4274/jcrpe.2784

• Polycystic ovary syndrome
• single nucleotide polymorphism
• Chinese Han women

Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 5-7% of reproductive age women worldwide. The aim of our study was to explore the PCOS-related single nucleotide polymorphism (SNP) associations between common genetic variants and PCOS risk in a Han Chinese women population. @@@ Methods: In this case-control study, 285 Chinese Han women aged 28.50 +/- 6.858 years with PCOS and 299 controls of a mean age of 32.66 +/- 7.018 years were compared. We selected recently published genome-wide association studies (GWAS) which identified several genetic loci in PCOS. All the SNPs were genotyped by Sequenom Mass-ARRAY technology. Associations between the gene and the risk of PCOS were tested using various genetic models by Statistical Package for the Social Sciences and Plink. @@@ Results: We found that rs705702 in the RAB5B/SUOX was associated with PCOS (odds ratio=1.42; 95% confidence interval=1.08-1.87, p=0.011) and increased the PCOS risk. The genotypic model analysis also showed that rs705702 was associated with PCOS risk. @@@ Conclusion: Our results suggest that SNPs rs705702 in gene RAB5B/SUOX was associated with PCOS in Han Chinese women.

• 出版日期2016-12
• 单位西北大学; 西安交通大学