How to detect carbapenemase producers? A literature review of phenotypic and molecular methods

作者：Hammoudi D^*; Moubareck C Ayoub; Sarkis D Karam

来源：Journal of Microbiological Methods, 2014, 107: 106-118.

DOI：10.1016/j.mimet.2014.09.009

• Carbapenemases
• Detection
• Screening
• Phenotypic methods
• Molecular methods

This review describes the current state-of-art of carbapenemase detection methods. Identification of carbapenemases is first based on conventional phenotypic tests including antimicrobial susceptibility testing, modified-Hodge test and carbapenemase-inhibitor culture tests. Second, molecular characterization of carbapenemase genes by PCR sequencing is essential. Third, innovative biochemical and spectrometric detection may be applied.

• 出版日期2014-12