An Eco-Friendly Asymmetric Organocatalytic Conjugate Addition of Malonates to ,-Unsaturated Aldehydes: Application on the Synthesis of Chiral Indoles

作者：Feu Karla Santos; Deobald Anna Maria; Narayanaperumal Senthil; Correa Arlene G; Paixao Marcio Weber^*

来源：European Journal of Organic Chemistry, 2013, 2013(26): 5917-5922.

DOI：10.1002/ejoc.201300431

• Synthetic methods
• Organocatalysis
• Michael addition
• Green chemistry
• Nitrogen heterocycles

The asymmetric Michael addition of malonates to ,-unsaturated aldehydes using a modified JOrgensen-Hayashi organocatalyst in EtOH:brine solvent media is reported. The procedure proceeds smoothly to afford the corresponding Michael adducts in good yields with excellent enantioselectivities. The resulting Michael adducts represent excellent building blocks for the synthesis of chiral indoles.

• 出版日期2013-9