Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation

作者：Jung Eunsun; Lee Jung A; Shin Seoungwoo; Roh Kyung Baeg; Kim Jang Hyun; Park Deokhoon^*

来源：Molecules, 2013, 18(12): 15724-15736.

DOI：10.3390/molecules181215724

• post-inflammatory pigmentation
• madecassoside
• PAR-2
• UVR

Madecassoside (MA), a pentacyclic triterpene isolated from Centella asitica (L.), is used as a therapeutic agent in wound healing and also as an anti-inflammatory and anti-aging agent. However, the involvement of MA in skin-pigmentation has not been reported. This study was conducted to investigate the effects of MA on ultraviolet (UV)-induced melanogenesis and mechanisms in a co-culture system of keratinocytes and melanocytes. MA significantly inhibited UVR-induced melanin synthesis and melanosome transfer in the co-culture system. These effects were further demonstrated by the MA-induced inhibition of protease-activated receptor-2 expression and its signaling pathway, cyclooxygenase-2, prostaglandin E2 and prostaglandin F2 alpha in keratinocytes. The clinical efficacy of MA was confirmed on artificially tanned human skin. MA significantly reduced UV-induced melanin index at 8 weeks after topical application. Overall, the study demonstrated significant benefits of MA use in the inhibition of hyperpigmentation caused by UV irradiation.

• 出版日期2013-12