A new synthetic 2 %26apos;-hydroxy-2,4,6-trimethoxy-5 %26apos;,6 %26apos;-naphthochalcone induces G2/M cell cycle arrest and apoptosis by disrupting the microtubular network of human colon cancer cells

作者：Lee Jong Min; Lee Mi So; Koh Dongsoo; Lee Young Han; Lim Yoongho^*; Shin Soon Young

来源：Cancer Letters, 2014, 354(2): 348-354.

DOI：10.1016/j.canlet.2014.08.041

• 2 %26apos
• -Hydroxy-2,4,6-trimethoxy-5 %26apos
• ,6 %26apos
• -naphthochalcone
• Tubulin polymerization
• G2/M arrest
• Apoptosis
• Caspase-2

Methoxylated chalcones exert antitumor activities. In the present study, we characterized the cytotoxicity of methylated chalcone derivatives against human colon cancer cells. We synthesized a group of methoxychalcones and explored the molecular mechanisms underlying inhibition of tumor growth by these materials. A new synthetic methoxychalcone, 2%26apos;-hydroxy-2,4,6-trimethoxy-5%26apos;,6%26apos;-naphthochalcone (named HMNC-74), most effectively inhibited the clonogenicity of SW620 colon cancer cells. Mechanistically, HMNC-74 triggered cell cycle arrest at G(2)/M phase, followed by an increase in apoptotic cell death. Our results indicate that the cytotoxicity of the novel compound HMNC-74 involves the disruption of microtubular networks.

• 出版日期2014-11-28