A Noninvasive Tumor Oxygenation Imaging Strategy Using Magnetic Resonance Imaging of Endogenous Blood and Tissue Water

作者：Zhang Zhongwei^*; Hallac Rami R; Peschke Peter; Mason Ralph P

来源：Magnetic Resonance in Medicine, 2014, 71(2): 561-569.

DOI：10.1002/mrm.24691

• tumor
• oxygenation
• R-1
• R-2
• diffusion
• IVIM

PurposeTo present a novel imaging strategy for noninvasive measurement of tumor oxygenation using MR imaging of endogenous blood and tissue water.
Theory and MethodsThe proposed approach for oxygen partial pressure (pO(2)) estimation is based on intravoxel incoherent motion diffusion MRI and the dependence of the blood R-2 relaxation rate on the inter-echo spacing measured using a multiple spin-echo Carr-Purcell-Meiboom-Gill sequence and weak-field diffusion model. The accuracy of the approach was validated by comparison with F-19 MRI oximetry.
ResultsThe results in eight rats at 4.7 T showed that tumors have longer T-1 (1980186 ms) and T-2 (59 +/- 9 ms) relaxation times, heterogeneous blood volume fraction (0.23 +/- 0.1), oxygen saturation level (Y) (0.53 +/- 0.12), and pO(2) (36 +/- 15 mmHg) distributions compared with normal muscle (T-1 1480 +/- 86 ms, T-2 29 +/- 2 ms, blood volume fraction 0.22 +/- 0.03, Y 0.49 +/- 0.06, and pO(2) 39 +/- 5 mmHg). pO(2) estimates based on the novel H-1 approach were essentially identical with F-19 observations.
ConclusionThe study indicates that noninvasive measurement of tumor pO(2) using H-1 MRI derived multiparametric maps is feasible and could become a valuable tool to evaluate tumor hypoxia. Magn Reson Med 71:561-569, 2014.

• 出版日期2014-2