Antiviral Triterpenoid Saponins from the Roots of Ilex asprella

作者：Zhou, Min; Xu, Min; Ma, Xiao-Xia; Zheng, Kai; Yang, Ke; Yang, Chong-Ren; Wang, Yi-Fei; Zhang, Ying-Jun^*

来源：Planta Medica, 2012, 78(15): 1702-1705.

DOI：10.1055/s-0032-1315209

• Ilex asprella
• Aquifoliaceae
• sulfur-containing triterpenoid saponins
• asprellanosides A and B
• antiviral

Two new sulfur-containing triterpenoid saponins, asprellanosides A (1) and B (2), were isolated from the roots of Ilex asprella, together with 10 known compounds (3-12). An in vitro anti-HSV-1 activity test of the isolates (1-4, 6-7, and 9-12) showed that only asprellanoside A (1) and oblonganoside H (6) exhibited anti-HSV-1 activity with TIC values of 0.14 and 0.18 mM, respectively.

• 出版日期2012-10
• 单位中国科学院; 中国科学院昆明植物研究所