Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa

作者：Chia, Yi Chen; Chang, Fang Rong; Wang, Jinn Chyi; Wu, Chin Chung; Chiang, Michael Y N; Lan, Yu Hsuan; Chen, Keh Shaw^*; Wu, Yang Chang

来源：Molecules, 2008, 13(1): 122-128.

DOI：10.3390/molecules13010122

• Murraya omphalocarpa
• coumarin
• epimurpaniculol senecioate
• X-ray
• antiplatelet

Using a bioactivity-guided fractionation method, two coumarins: minumicroline acetonide (1) and epimurpaniculol senecioate (2), were isolated from the leaves of Murraya omphalocarpa Hayata (Rutaceae). Compound 1 had been previously synthesized and was now isolated from natural sources for the first time, and compound 2, possessing a negative optical rotation value, is new. The structures and their stereochemistry were fully elucidated on the basis of spectroscopic and X-ray crystallographic techniques. Both compounds 1 and 2 are active in the antiplatelet aggregation assay. Interestingly, the possible acetonide artifact 1 displayed significant antiplatelet aggregation induced not only by AA and collagen but also by platelet activating factor (PAF).

• 出版日期2008-1
• 单位中山大学