Efficacy and tolerance of yeast cell wall as an immunostimulant in the diet of Japanese seabass (Lateolabrax japonicus)

作者：Yu, H. H.; Han, F.; Xue, M.^*; Wang, J.; Tacon, P.; Zheng, Y. H.; Wu, X. F.; Zhang, Y. J.

来源：Aquaculture, 2014, 432: 217-224.

DOI：10.1016/j.aquaculture.2014.04.043

• Yeast cell wall
• Lateolabrax japonicas
• Efficacy
• Tolerance
• Immune response
• Bacterial challenge

The effects of dietary yeast cell wall (YCW) on the growth, immune response and cumulative survival rate after Aeromonas veronii challenge were investigated in Japanese seabass, Lateolabrax japonicas. Six high soybean meal (SBM) inclusion diets were prepared with YCW levels at 0 (Y0), 250 (Y1), 500 (Y2), 1000 (Y3), 2000 (Y4), and 20,000 (Y5) mg/kg, respectively. The highest YCW level (20,000 mg/kg) was designed as the 10 fold of the highest recommended level (2000 mg/kg) for tolerance evaluation. In addition, a positive control (FM) with higher fishmeal level and a negative control (Fla) with 4 mg/kg flavomycin based on Y0 diet were designed. Each diet was fed to six replicates of 30 Japanese seabass (183 +/- 0.01 g) for 72 days. The growth performance of YO group was lower than that of FM group. Optimal levels (1000-2000 mg/kg) of baker's YCW improved the growth performance and intestinal mucus development of Japanese seabass, while 500 mg/kg YCW enhanced immune response and cumulative survival after challenged with A. veronii. Flavomycin inclusion negatively affected the growth and immune response of fish. The present study proved that the highest recommended dose of YCW was 2000 mg/kg, and 10 fold of safety margin was obtained.

• 出版日期2014-8-20
• 单位中国农业科学院; 中国海洋大学