microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma

作者：Jiang, Xue-Mei; Yu, Xiang-Nan; Liu, Tao-Tao; Zhu, Hai-Rong; Shi, Xuan; Bilegsaikhan, Enkhnaran; Guo, Hong-Ying; Song, Guang-Qi; Weng, Shu-Qiang; Huang, Xiao-Xi; Dong, Ling; Janssen, Harry L. A.; Shen, Xi-Zhong; Zhu, Ji-Min^*

来源：Biomedicine & Pharmacotherapy, 2018, 105: 1147-1154.

DOI：10.1016/j.biopha.2018.06.097

• microRNA-19a-3p
• Hepatocellular carcinoma
• Metastasis
• Chemoresistance

microRNA-19a-3p (miR-19a-3p) has been reported to regulate cell proliferation in hepatocellular carcinoma (HCC), but its role in HCC metastasis remains unknown. In this study, miR-19a-3p was noted to be upregulated in HCC specimens and cell lines. Aberrant expression of miR-19a-3p stimulated HCC cell metastasis, and phosphatase and tensin homolog (PTEN) was shown to be a direct target of miR-19a-3p. miR-19a-3p-mediated HCC metastasis was reversed by restoration of PTEN or could be imitated by silencing of PTEN. Modulation of miR-19a-3p also altered expression of phosphorylated Akt, a downstream mediator of PTEN. Moreover, aberrant expression of miR-19a-3p induced sorafenib resistance by regulating the PTEN/Akt pathway. In conclusion, ectopic expression of miR-19a-3p contributes to HCC metastasis and chemoresistance by modulating PTEN expression and the PTEN-dependent pathways.

• 出版日期2018-9
• 单位中南大学; 复旦大学