A mechanistic investigation of Biginelli reaction under base catalysis

作者：Raj M Kamal; Rao H Surya Prakash; Manjunatha Sulur G; Sridharan R; Nambiar Sudhir; Keshwan Jaikumar; Rappai Jayan; Bhagat Sagar; Shwetha B S; Hegde Dinesh; Santhosh U^*

来源：Tetrahedron Letters, 2011, 52(28): 3605-3609.

DOI：10.1016/j.tetlet.2011.05.011

• Biginelli reaction
• Dihydropyrimidine
• Multicomponent reactions
• Accurate mass TOF LC-MS-ESI

The mechanism of the three component base mediated Biginelli dihydropyrimidines synthesis was investigated using Accurate Mass TOF LC-MS-ESI and Tandem TOF LC-MS-ESI. We suggest hemiaminal as a possible intermediate leading to the formation of Biginelli product. Under our current experimental conditions we did not observe any bis-ureide as reported by ji et al.

• 出版日期2011-7-13