Access to Bacteriologic-Based Diagnosis in Smear Positive Retreatment Tuberculosis Patients in Rural China: A Cross-Sectional Study in Three Geographic Varied Provinces

作者：Zhou, Changming; Jiang, Weili; Yuan, Li; Lu, Wei; He, Jinge; Zhao, Qi^*; Xu, Biao

来源：PLos One, 2016, 11(1): e0146340.

DOI：10.1371/journal.pone.0146340

• DRUG-RESISTANT TUBERCULOSIS
• MULTIDRUG-RESISTANT
• HEALTH SYSTEM
• TB DIAGNOSIS
• PROGRAM
• EPIDEMIOLOGY
• TRANSMISSION
• MANAGEMENT
• MIGRANTS
• BARRIERS

Objective @@@ To determine factors influencing the utilization and accessibility to bacteriologic-based tuberculosis (TB) diagnosis among sputum smear positive (SS+) retreatment TB patients, and to develop strategies for improving the case detection rate of MDR-TB in rural China. @@@ Study Design and Setting @@@ A cross-sectional study of SS+ TB retreatment patients was conducted in eight counties from three provinces with different implementation period and strategy of MDR-TB program in China. Demographic and socioeconomic parameters were collected by self-reporting questionnaires. Sputum samples were collected and cultured by the laboratory of county-designated TB clinics and delivered to prefectural Centers for Disease Prevention and Control (CDC) labs for DST with 4 first-line anti-TB drugs. @@@ Results @@@ Among the 196 SS+ retreatment patients, 61.22% received culture tests during current treatment. Patients from more developed regions (OR = 24.0 and 3.6, 95% CI: 8.6-67.3 and 1.1-11.6), with better socio-economic status (OR = 3. 8, 95% CI: 1.3-10.7), who had multiple previous anti-TB treatments (OR = 5.0, 95% CI: 1.6-15.9), and who failed in the most recent anti-TB treatment (OR = 2.6, 95% CI: 1.0-6.4) were more likely to receive culture tests. The percentage of isolates resistant to any of first-line anti-TB drugs and MDR-TB were 50.0% (95% CI: 39.8%-60.2%) and 30.4%(95% CI: 21.0%-39.8%) respectively. @@@ Conclusions @@@ Retreatment SS+ TB patients, high risk MDR-TB population, had poor utilization of access to bacteriologic-based TB diagnosis, which is far from optimal. The next step of anti-TB strategy should be focused on how to make bacteriological-based diagnosis cheaper, safer and more maneuverable, and how to assure the DST-guided treatment for these high-risk TB patients.

• 出版日期2016-1-11
• 单位复旦大学; 江苏省疾病预防控制中心