Anti-inflammatory terpenoids from Cyperus rotundus rhizomes

作者：Ibrahim Sabrin Ragab Mohamed^*; Mohamed Gamal Abdallah; Khayat Maan Talaat Abdullah; Zayed Mohamed Fathalla; El-Kholy Amal Abd-Elmoneim Soliman

来源：Pakistan Journal of Pharmaceutical Sciences, 2018, 31(4): 1449-1456.

• Cyperus rotundus
• cyperaceae
• terpenoids
• cyperalin a
• anti-inflammatory

Phytochemical investigation of the methanolic extract of Cyperus rotundus L. (Cyperaceae) rhizomes afforded a new norterpenoid with an unprecedented carbon skeleton, namely cyperalin A (1) and sugetriol triacetate (2). Their structures were identified by using advanced spectroscopic technique such as UV, IR, ID (1H and C-13), 2D (1H-1H COSY, HSQC, HMBC, and NOESY) NMR, and HRESIMS as well as comparison with literature data. The isolated compounds were evaluated for their anti-inflammatory activity. Compound 1 displayed the highest inhibitory activity of PGE2, COX-2, and LOX-5 with IC(50)s 0.22, 1.03, and 1.37 mu M, respectively compared to indomethacin (IC(50)s 0.15, 0.69, and 0.81 mu M, respectively). Moreover, 2 demonstrated significant activity with IC(50)s 0.57 (PGE2), 1.74 (COX-2) and 2.03 (LOX-5) mu M.

• 出版日期2018-7