ABNORMALITIES IN SERUM PROTEINS IN THE COURSE OF BABESIOSIS IN DOGS

作者：Zygner Wojciech^*; Gojska Zygner Olga; Wedrychowicz Halina

来源：Bulletin of the Veterinary Institute in Pulawy, 2011, 55(1): 59-65.

• dogs
• Babesia
• canine babesiosis
• blood proteins
• blood protein disorders

The objectives of this study were to evaluate the serum protein electrophoresis pattern in dogs infected with B. canis, and correlation between haematocrit and albumin/globulin ratio. The infection with B. cam's was confirmed by PCR and sequencing of PCR products. Total scrum protein concentrations were determined by a clinical chemistry analyser. Albumin, alpha(1)-, alpha(2)-, beta(1)-, beta(2)-, and gamma-globulin concentrations were assayed by densitometric analysis after electrophoretic separation of serum proteins on agarose gel. The most common disorders in affected dogs were decreased alpha-globulin fractions, increased beta-globulin concentration, increased albumin/globulin (A/G) ratio, and hypoglobulinaemia. A decrease in alpha(1)- and alpha(2)-globulin concentration was detected accordingly in 54.8% and 32.3% of dogs. An increase in beta(1)- and beta(2)-globulin concentration. and increased A/C ratio was detected accordingly in 38.7%, 51.6%, and 38.7% of dogs. Hypoglobulinaemia was detected in 32.3% dogs. Changes detected in this study probably result from haemolysis, hypertransferrinaemia, increased C3a protein concentration (complement), and dehydration.

• 出版日期2011