A simple and efficient synthesis of new mono- and bis([1,2,4]-oxadiazol)-benzaldehyde building blocks

作者：Crestey Francois; Lebargy Cyril; Lasne Marie Claire; Perrio Cecile^*

来源：Synthesis, 2007, (21): 3406-3410.

DOI：10.1055/s-2007-990834

• mono- and bis-benzaldehyde
• 1,2,4-oxadiazole
• benzamidoxime
• O-acylation
• acetal deprotection

An efficient approach to bis([1,2,4]-oxadiazol)benzaldehydes as well as the corresponding mono-benzaldehyde derivatives has been developed starting from benzamidoxime, which is readily obtained from 4-cyanobenzaldehyde. All these new compounds were synthesized in a high-yielding, five-step procedure with few and simple purifications.

• 出版日期2007-11-2
• 单位中国地震局