3D spongy graphene-modified screen-printed sensors for the voltammetric determination of the narcotic drug codeine

作者：Mohamed Mona A^*; El Gendy Dalia M; Ahmed Nashaat; Banks Craig E; Allam Nageh K^*

来源：Biosensors and Bioelectronics, 2018, 101: 90-95.

DOI：10.1016/j.bios.2017.10.020

• Green synthesis
• Spongy graphene
• Screen-printed sensors
• Codeine
• Adenine

Adenine-functionalized spongy graphene (FSG) composite, fabricated via a facile and green synthetic method, has been explored as a potential electrocatalyst toward the electroanalytical sensing of codeine phosphate (COD). The synthesized composite is characterized using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray powder diffraction, UV-vis absorption spectroscopy, scanning electron microscopy, high resolution transmission electron microscopy (HRTEM), and thermogravimetric analysis. The FSG was electrically wired via modification upon screen-printed (macro electrode) sensors, which behave as a hybrid electrode material for the sensitive and selective codeine phosphate (COD) determination in the presence of paracetamol (PAR) and caffeine (CAF). The FSG- modified sensor showed an excellent electrocatalytic response towards the sensing of COD with a wide linear response range of 2.0 x 10(-8)-2.0 x 10(-4) M and a detection limit (LOD) of 5.8 x 10(-9) M, indicating its potential for the sensing of COD in clinical samples and pharmaceutical formulations.

• 出版日期2018-3-15