Accelerator mass spectrometry analysis of C-14-oxaliplatin concentrations in biological samples and C-14 contents in biological samples and antineoplastic agents

作者：Toyoguchi Teiko^*; Kobayashi Takeshi; Konno Noboru; Shiraishi Tadashi; Kato Kazuhiro; Tokanai Fuyuki

来源：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms , 2015, 361: 559-563.

DOI：10.1016/j.nimb.2015.03.062

• Accelerator mass spectrometry
• C-14-oxaliplatin
• Urine
• Antineoplastic agents

Accelerator mass spectrometry (AMS) is expected to play an important role in microdose trials. In this study, we measured the C-14 concentration in C-14-oxaliplatin-spiked serum, urine and supernatant of fecal homogenate samples in our Yamagata University (YU) AMS system. The calibration curves of C-14 concentration in serum, urine and supernatant of fecal homogenate were linear (the correlation coefficients were >= 0.9893), and the precision and accuracy was within the acceptance criteria.
To examine a C-14 content of water in three vacuum blood collection tubes and a syringe were measured. C-14 was not detected from water in these devices. The mean C-14 content in urine samples of 6 healthy Japanese volunteers was 0.144 dpm/mL, and the intra-day fluctuation of C-14 content in urine from a volunteer was little. The antineoplastic agents are administered to the patients in combination. Then, C-14 contents of the antineoplastic agents were quantitated. C-14 contents were different among 10 antineoplastic agents; C-14 contents of paclitaxel injection and docetaxel hydrate injection were higher than those of the other injections.
These results indicate that our quantitation method using YU-AMS system is suited for microdosing studies and that measurement of baseline and co-administered drugs might be necessary for the studies in low concentrations.

• 出版日期2015-10-15