An Efficient Synthesis of Quinoxalinone Derivatives as Potent Inhibitors of Aldose Reductase

作者：Yang Yanchun; Zhang Shuzhen; Wu Bobin; Ma Mingming; Chen Xin; Qin Xiangyu; He Minlan; Hussain Saghir; Jing Chaojun; Ma Bing; Zhu Changjin^*

来源：ChemMedChem, 2012, 7(5): 823-835.

DOI：10.1002/cmdc.201200054

• chemoselectivity
• enzymes
• inhibitors
• quinoxalines
• regioselectivity
• structure-activity relationships

A novel and facile synthesis of quinoxalinone derivatives was developed in which a wide range of 3-chloroquinoxalin-2(1H)-ones as key intermediates can be generated chemo- and regioselectively in good yields from corresponding quinoxaline-2,3(1H,4H)-diones. This new protocol is arguably superior, as it allows the design and preparation of a variety of bioactive quinoxaline-based compounds, which are particularly effective in the treatment of diabetes and its complications. Through this procedure, a new class of quinoxalinone-based aldose reductase inhibitors were synthesized successfully. Most of the inhibitors, with an N1-acetic acid head group and a substituted C3-phenoxy side chain, proved to be potent and selective. Their IC50 values ranged from 11.4 to 74.8 nM. Among them, 2-(3-(4-bromophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid and 2-(6-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid were the most active. Structureactivity relationship and molecular docking studies highlighted the importance of the ether spacer in the C3-phenoxy side chains, and provided clear guidance on the contribution of substitutions both at the core structure and the side chain to activity.

• 出版日期2012-5
• 单位北京理工大学