Antibodies are forever: a study using 12-26-year-old expired antibodies

作者:Argentieri Maria C; Pilla Daniela; Vanzati Alice; Lonardi Silvia; Facchetti Fabio; Doglioni Claudio; Parravicini Carlo; Cattoretti Giorgio*
来源:Histopathology, 2013, 63(6): 869-876.
DOI:10.1111/his.12225

摘要

AimsThe aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label. %26lt;br%26gt;Methods and resultsFour independent laboratories tested a small number of diagnostic antibodies kept at +4 degrees C for 12-26years, and found them to work perfectly on routine histology sections. %26lt;br%26gt;ConclusionsDiagnostic antibodies may have a workable half-life in excess of 10years, and the emphasis on performance should shift to the preservation of antigenic targets in the tissue.

  • 出版日期2013-12