Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma

作者：Ramos Caroline Steglich; Goncalves Andreia Souza; Marinho Larissa Cardoso; Gomes Avelino Melissa Ameloti; Saddi Vera Aparecida; Lopes Aryanne Cristina; Simoes Renata Toscano; Wastowski Isabela Jube^*

来源：Human Immunology, 2014, 75(7): 667-672.

DOI：10.1016/j.humimm.2014.04.005

• Breast cancer
• HLA-G
• Polymorphism
• Tumor escape

The human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule predominantly expressed in trophoblastic placental cells to protect the fetus during pregnancy. However, evidence has shown that this molecule may be implicated in the immune escape mechanism of tumor cells. Thus, the aim of this study was to evaluate the frequency of 14-bp insertion/deletion HLA-G polymorphism, as well as the expression of this molecule in patients with invasive breast ductal carcinoma (IDC). A significant association between the expression of HLA-G and the presence of metastasis in lymph nodes (p = 0.01) was observed and the expression of HLA-G was significantly higher in patients with shorter survival time (p = 0.03). The analysis suggests that the polymorphism observed in patients with DC may be inducing a higher expression of the HLA-G molecule, which may possibly contribute to shorter survival time and a worse clinical prognosis for such patients.

• 出版日期2014-7