Ambulatory arterial stiffness indices and target organ damage in hypertension

作者：Angel Gomez Marcos Manuel; Ignacio Recio Rodriguez Jose; Carmen Patino Alonso Ma; Gomez Sanchez Leticia; Agudo Conde Cristina; Gomez Sanchez Marta; Rodriguez Sanchez Emiliano; Garcia Ortiz Luis

来源：BMC Cardiovascular Disorders, 2012, 12: 1.

DOI：10.1186/1471-2261-12-1

• Ambulatory arterial stiffness index
• home arterial stiffness index
• ambulatory blood pressure monitoring
• home blood pressure
• target organ damage

Background: The present study was designed to evaluate which arterial stiffness parameter - AASI or the home arterial stiffness index (HASI) - correlates best with vascular, cardiac and renal damage in hypertensive individuals. %26lt;br%26gt;Methods: A cross-sectional study was carried out involving 258 hypertensive patients. AASI and HASI were defined as the 1-regression slope of diastolic over systolic blood pressure readings obtained from 24-hour recordings and home blood pressure over 6 days. Renal damage was evaluated by glomerular filtration rate (GFR) and microalbuminuria; vascular damage by carotid intima-media thickness (IMT), pulse wave velocity (PWV) and ankle/brachial index (ABI); and left ventricular hypertrophy by the Cornell voltage-duration product (VDP) and the Novacode index. %26lt;br%26gt;Results: AASI and HASI were not correlated with microalbuminuria, however AASI and HASI-blood pressure variability ratio (BPVR) showed negative correlation with GRF. The Cornell PDV was positively correlated with AASI-BPVR-Sleep (r = 0.15, p %26lt; 0.05) and the left ventricular mass index with HASI-BPVR (r = 0.19, p %26lt; 0.01). Carotid IMT and PWV were positively correlated with all the parameters except the HASI, while ABI was negatively correlated with AASI and Awake-AASI. After adjusting for age, gender and 24 hours heart rate, statistical significance remains of the IMT with AASI, Awake AASI and AASI-BPVR. PWV with the AASI, Awake-AASI and Sleep-AASI. ABI with AASI and Awake-AASI. Odd Ratio to presence target organ damage was for AASI: 10.47(IC95% 1.29 to 65.34), Awake-AASI: 8.85(IC95% 1.10 to 71.04), Sleep-AASI: 2.19(IC95% 1.10 to 4.38) and AASI-BPVR-night: 4.09 (IC95% 1.12 to 14.92). %26lt;br%26gt;Conclusions: After adjusting for age, gender and 24-hour heart, the variables that best associated with the variability of IMT, PWV and ABI were AASI and Awake-AASI, and with GFR was HASI-BPVR.

• 出版日期2012-1-27